It’s official, statins do not have any side effects. Some of you will have noted that researchers have now decided that statins do not have any side effects at all. To be pedantic, the correct term is not side- effects, it is drug related adverse events. Updated May 19, 2017 76 countries with anti-homosexuality laws (or 71, or 72, or 78) A total of 72 countries have criminal laws against sexual activity by lesbian. Some of you will have noted that researchers have now decided that statins do not have any side effects at all. To be pedantic, the correct term is not side-effects. A side effect can be positive, or negative. In order to prove that statins cause no adverse events, a paper was published in the Lancet entitled: ‘Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo- Scandinavian Cardiac Outcomes Trial—Lipid- Lowering Arm (ASCOT- LLA): a randomised double- blind placebo- controlled trial and its non- randomised non- blind extension phase.’A virtually impenetrable title which could mean almost anything. But the key message can be found here: ‘These analyses illustrate the so- called nocebo effect, with an excess rate of muscle- related AE reports only when patients and their doctors were aware that statin therapy was being used and not when its use was blinded. These results will help assure both physicians and patients that most AEs associated with statins are not causally related to use of the drug and should help counter the adverse effect on public health of exaggerated claims about statin- related side- effects.’Funding: Pfizer, Servier Research Group, and Leo Laboratories. Statement by authors in original ASCOT study [The Lancet vol 3. April 5th 2. 00. 3. Pp. 11. 49- 1. 15. ![]() The Anglo- Scandinavian Outcomes Trial (ASCOT) is an independent, investigator- initiated and investigator- led multicentre, randomised trial designed to compare two antihypertensive treatment strategies for the prevention of CHD events…’Funding of the original ASCOT study: Pfizer, Servier Research Group and Leo Laboratories. The ASCOT study was published over fifteen years ago. There was a lot of noise about this study on the radio, newspaper and television. At least there was in the UK. Professor Peter Sever, one of the authors, and a key investigator, stated on the radio, that the inserts warning of drug related adverse effects should be removed from the packaging, as they simply encourage patients to believe that they are suffering from adverse effects. Go inside the world of producers, traffickers, dealers, users, doctors, and cops—who all make up the $320-billion-dollar drugs industry.He also stated that statins caused muscle problems in less than one in ten thousand patients. I tend to disagree with him. I was asked to be interviewed on various radio stations, including BBC radio Scotland, and to write a newspaper article for the Scotsman newspaper. It went as follows: The Great Statin Con. Yesterday, I was asked to appear on various programmes to discuss a study ‘proving’ that statins cause no side- effects at all. Or, at most, they may cause muscle pains in around one in ten thousand people, no more. At the same time, statins save thousands of lives a year. Therefore, everyone should take them, and patients should ignore scaremongering doctors – such as me I suppose – who state that side- effects are common, and potentially serious. On the radio, Professor Peter Sever, the lead author of the study, suggested that the leaflets warning of side effects should be removed, because once a patient reads that there may be side effects, they will be far more likely to suffer from them, and report them. The so- called ‘nocebo’ effect. The opposite of the placebo effect, whereby people taking medicines think they will get better, or that their pain will be reduced. There is no doubt that the nocebo effect is real, although the placebo effect is also real, so do these two effects not just cancel each other out? This is a difficult area of medicine, disentangling what is real, from what is imagined. However, I watched my father in law become unable to walk, whilst taking statins. We were pushing him around in a wheelchair until, eventually, he agreed to stop his statins. At which point he became able to walk a good distance again, and even climb stairs again. A ‘nocebo’ effect? All in the mind? No, of course not. I had a patient with such severe abdominal pains that she was going to undergo an investigative laparotomy to establish what was causing them. No investigations had revealed anything. I suggested she stop the statins and the pains were completely gone in two days. All in the mind? I have spoken to many other GPs who have reported seeing side effects in many patients. I suppose if you are trying to push statins as hard as possible, and you built your academic reputation on running trials on statins, you will naturally want to push them as hard as possible. Some ‘experts’ have even suggested putting statins in the water supply. But this latest report pushes things to a completely ridiculous point. Can I, as a GP, simply tell patients reporting side- effect that ‘you do not have a side effect, they do not exist, it is simply in your mind.’ No, this would be completely ridiculous, and a total denial of your job, which is to listen to what patients tell you. Not to take a horribly, I know best, paternalistic position. On the other hand, the benefits of statins have been hyped to an almost completely ridiculous degree. We are told that they reduce the risk of having a heart attack by 3. The reality is, that unless you have had a previous heart attack, statins have no effect on overall mortality. To put that another way, they don’t save lives. They don’t even prevent heart attacks or strokes in women with no previous history of heart disease. The statistic you really want to know about statins is the following. If you have had a heart attack, or stroke, and take a statin for five years, you will increase your life expectancy by 4. Balance that against a twenty per cent chance of having side effects, some of which are very unpleasant and long- lasting, and you can see why I am not a fan of statins. Ends. Currently I am sifting through the original ASCOT paper to find out exactly what they did study, and what they found, and suchlike. The problem with trying to get to grips with research like this is that there are figures, and more figures, and data and exclusion criteria, and things that are not fully explained. So, it is difficult to make any statement about this entire saga, without many hours of detailed research. However, I can certainly comment on the key finding from the recent Lancet ‘nocebo’ paper. Key or not, it is the finding that they made the most noise about.‘During the non- blinded non- randomised phase, muscle- related AEs (adverse events) were reported at a significantly higher rate by participants taking statins than by those who were not (1. To translate 1. 61 people (out of more than six thousand) complained of muscle pain whilst taking the statin, and 1. In total 3. 7 more people complained of muscle pain on the statin. This is not, what I would call, a lot. It was an absolute increase, in the risk of reporting adverse effects, of 0. Compare and contrast this figure with the findings of the ‘Statin USAGE’ study. As far as I know, this was the largest study to look at why people take, then stop taking, statins: ‘The USAGE survey – “Understanding Statin use in Ama and Gaps in Education” – is the largest known cholesterol survey conducted in the U. S., involving more than 1. The USAGE survey explores patient perceptions, attitudes, behaviors and concerns about statins, the most commonly prescribed medications to treat high cholesterol.’ http: //www. Pages/about- survey- respondents. A number of things were found. The most important of which, is just how many people stopped taking their statins after one year. A pretty staggering 7. Why did they stop?‘More than six in ten respondents (6. Only 1. 2% of respondents cited lack of efficacy in cholesterol management as a reason for stopping their medication. On average, respondents who experienced side effects due to their statin stopped after trying two different statins. Three out of ten respondents experienced side effects of muscle pain and/or weakness, and 3. So, on one hand, what the Lancet study found was that 0. On the other hand, the Statin USAGE survey found that 3. Now, try to get those two figures to match up. You could argue that the nocebo effect can only account for 0. Therefore, the other 2. Statin USAGE study – 0. You could argue that randomised controlled clinical trials do not reflect the experience of taking medication in the real- world environment. You could say that you can believe one of these studies, but not both.
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Hz Motion. Flow technology. The XBR8 line offers two screen sizes; the 4. KDL- 4. 6XBR8)[1. September 2. 9, 2. The second model, the 5. KDL- 5. 5XBR8)[1. October 2. 00. 8.[needs update]Green TV[edit]For sale in Japan on July 3. Sony's green product, a new flat- panel 3. TV for 1. 50,0. 00 yen (US$1,4. ![]() ![]() Sony Bravia Software Update UsbaspBRAVIA KDL- 3. 2JE1 offers ecological consumers the advantage of 7. For consumers who rely on electricity generated from carbon dioxide emitting sources, it reduces carbon dioxide emissions totaling 7. Mobile phones[edit]Sony uses a BRAVIA image processing engine in high- end mobile devices produced by its Sony Ericsson communications arm (now Sony Mobile Communications), starting with the Xperia arc model in 2. Subsequent flagship models of Sony's smartphone range such as the Xperia S, and Xperia Z use enhanced versions of the BRAVIA engine. In addition, BRAVIA brand phones have been produced by Sony/Sony Ericsson. BRAVIA brand phones are able to watch 1seg terrestrial television. A picture of a Sony logo during turning On with the Sony BRAVIA. FOMA SO9. 03i. TV (Released in June 2. FOMA SO9. 06i (Released in June 2. FOMA SO- 0. 1C (Sony Ericsson Xperia Arc) (Released in March 2. U1 (Released in December 2. S0. 04 (Released in May 2. S0. 05 (Released in November 2. S0. 04)Internals[edit]The LCD panels within BRAVIA TVs are manufactured by Sony corporation with a special architecture. Since 2. 01. 0, high end Bravia LX, HX and selected NX series use 1. Sony Bravia ASV panel.[citation needed] The 8th gen SPVA panel from Sony LCD continue to serve other midrange and budget Bravia models.[citation needed]Many Sony televisions with USB connectivity run Linux.[1. Upgrading and maintenance[edit]The software can be upgraded via a USB type A interface labeled "DMEx / service only" and via the Internet for later models. Memory Stick or USB. Depending upon the country and TV standard the Tuner may need a Service Device to update it. It appears that units manufactured through November 2. Asia and North America contained a software bug that prevented the device from powering up/down after 1. A free upgrade is available.[1. References[edit]. La tua Community di Viaggi e Vacanze. Minube è stato uno di quei siti che, come viaggiatore e fotografo, mi ha scatenato un amore a prima vista. Confesso che sono sempre stato molto scettico rispetto a quei siti web di viaggi che consigliano luoghi culturali, turistici, ecc. Forse perché, occupandomi di fotografía documentaria, tendo a cercare posti non così "visitati" o " conosciuti"; tuttavia, il fatto che molti utenti di Minube iniziassero a condividere i loro posti del cuore all'interno della web mi ha fatto vedere che Minube è un luogo molto personalizzabile e molto utile per avere ispirazioni, anche per scoprire cosa vedere in destinazioni recondite, anch'esse condivise da alcuni utenti. In poche parole, come dicevo all'inizio, il grande fascino di Minube è la sua comunità. Grazie a lei capisci che non è una web che vuole venderti qualcosa e basta; al contrario, ti può aiutare in ogni momento del tuo viaggio (gastronomía, ristoranti, luoghi di interesse, luoghi più appartati, trasporti, dove dormire..), non importa che tipo di viaggiatore tu sia. ![]() ![]() 156907 % 10995 governo 66938 país 64202 presidente 58923 r$ 58558 pessoa 5699 tempo 56098 empresa 52413 mês 46288 parte 43780 caso.Background Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials have been conducted, the relative. Lyberty.com's weekly/monthly splash page. (Yes, a splash page is old fashioned, but it's been a tradition here since 1999.). Viaggi e Vacanze - Minube è la community di viaggiatori e turisti dove scoprire destinazioni e condividere esperienze e idee di viaggio. |
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